Proteomics

Dataset Information

0

Senescence 2

ABSTRACT: Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Judith Coppinger 

PROVIDER: MSV000079932 | MassIVE | Tue Jul 19 18:00:00 BST 2016

SECONDARY ACCESSION(S): PXD001013

REPOSITORIES: MassIVE

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications

Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.

Pasillas Martina P MP   Shields Sarah S   Reilly Rebecca R   Strnadel Jan J   Behl Christian C   Park Robin R   Yates John R JR   Klemke Richard R   Gonias Steven L SL   Coppinger Judith A JA  

Molecular & cellular proteomics : MCP 20140705 1

Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectr  ...[more]

Similar Datasets

Proteomics Senescence 3
2016-07-19 | MSV000079924 | MassIVE
Proteomics Senescence 5
2016-07-19 | MSV000079931 | MassIVE
Proteomics Senescence 6
2016-07-22 | MSV000079989 | MassIVE
Proteomics Senescence 1
2016-07-19 | MSV000079929 | MassIVE
Proteomics Senescence 4
2016-07-19 | MSV000079930 | MassIVE
Proteomics Senescence 2 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
2015-08-21 | PXD001013 | Pride
Proteomics Senescence 6 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
2015-08-21 | PXD001017 | Pride
Proteomics Senescence 1 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
2015-08-21 | PXD001012 | Pride
Proteomics Senescence 4 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
2015-08-21 | PXD001015 | Pride
Proteomics Senescence 5 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation
2015-08-21 | PXD001016 | Pride