Proteomics

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Senescence 1

ABSTRACT: Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Dr Judith Coppinger 

PROVIDER: MSV000079929 | MassIVE | Tue Jul 19 17:53:00 BST 2016

SECONDARY ACCESSION(S): PXD001012

REPOSITORIES: MassIVE

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Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.

Pasillas Martina P MP   Shields Sarah S   Reilly Rebecca R   Strnadel Jan J   Behl Christian C   Park Robin R   Yates John R JR   Klemke Richard R   Gonias Steven L SL   Coppinger Judith A JA  

Molecular & cellular proteomics : MCP 20140705 1

Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectr  ...[more]

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