Dataset Information

Non-Small Cell Lung Cancer patients undergoing radical radiotherapy

ABSTRACT: Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patients undergoing radiotherapy. Identification of such markers would allow treatment options to be considered for more effective therapy. To enable the identification of appropriate protein biomarkers, plasma samples were collected from patients with non-small cell lung cancer before and during radiotherapy for longitudinal comparison following a protocol that carries sufficient power for effective discovery proteomics. Plasma samples from patients pre- and during radiotherapy who had survived >18 months were compared to the same time points from patients who survived <14 months using an 8 channel isobaric tagging tandem mass spectrometry discovery proteomics platform.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Lung Cancer

SUBMITTER: Michael Walker

LAB HEAD: Anthony Whetton

PROVIDER: PXD001052 | Pride | 2018-10-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	020812_pek_itraq2_33.wiff	Wiff
	020812_pek_itraq2_34.wiff	Wiff
	020812_pek_itraq2_35.wiff	Wiff
	020812_pek_itraq2_36.wiff	Wiff
	020812_pek_itraq2_37.wiff	Wiff

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Publications

Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value.

Walker Michael J MJ Zhou Cong C Backen Alison A Pernemalm Maria M Williamson Andrew J K AJ Priest Lynsey J C LJ Koh Pek P Faivre-Finn Corinne C Blackhall Fiona H FH Dive Caroline C Whetton Anthony D AD

EBioMedicine 20150619 8

Lung cancer is the most frequent cause of cancer-related death world-wide. Radiotherapy alone or in conjunction with chemotherapy is the standard treatment for locally advanced non-small cell lung cancer (NSCLC). Currently there is no predictive marker with clinical utility to guide treatment decisions in NSCLC patients undergoing radiotherapy. Identification of such markers would allow treatment options to be considered for more effective therapy. To enable the identification of appropriate pro ...[more]

PMID: 26425690

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