Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Jens Andersen
LAB HEAD: Henrik J. Ditzel
PROVIDER: PXD001087 | Pride | 2022-02-22
REPOSITORIES: Pride
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Løkkegaard Sanne S Elias Daniel D Alves Carla L CL Bennetzen Martin V MV Lænkholm Anne-Vibeke AV Bak Martin M Gjerstorff Morten F MF Johansen Lene E LE Vever Henriette H Bjerre Christina C Kirkegaard Tove T Nordenskjöld Bo B Fornander Tommy T Stål Olle O Lindström Linda S LS Esserman Laura J LJ Lykkesfeldt Anne E AE Andersen Jens S JS Leth-Larsen Rikke R Ditzel Henrik J HJ
NPJ breast cancer 20210104 1
Resistance to endocrine therapy in estrogen receptor-positive (ER<sup>+</sup>) breast cancer is a major clinical problem with poorly understood mechanisms. There is an unmet need for prognostic and predictive biomarkers to allow appropriate therapeutic targeting. We evaluated the mechanism by which minichromosome maintenance protein 3 (MCM3) influences endocrine resistance and its predictive/prognostic potential in ER<sup>+</sup> breast cancer. We discovered that ER<sup>+</sup> breast cancer cel ...[more]