Dataset Information

Inactivation of a NB-LRR plant immune-effector complex by post-translational modification

ABSTRACT: Modification of plant immune complexes by pathogen effectors can trigger strong immune responses mediated by the action of nucleotide binding-leucine rich repeat immune receptors. Although some strains of the pathogen Pseudomonas syringae harbor effectors that individually can trigger immunity, the plant’s response may be suppressed by other virulence factors. This work shows a new strategy for immune suppression. After injection into host cells, the suppressing effector binds to and acetylates multiple members of an immune complex, including another effector that on its own can trigger immunity. Acetylations modify serine, threonine, lysine and/or histidine residues in the targets resulting in the inactivation of the whole immune complex and increased growth of the pathogen.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Pseudomonas Syringae Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Plant Cell

SUBMITTER: Donald Wolfgeher

LAB HEAD: Jean T. Greenberg

PROVIDER: PXD001344 | Pride | 2016-05-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	130416_Greenberb_db3.fasta	Fasta
	130923_Greenberg_Gel2_HeavyAc_exp.pptx	Other
	131220_JL3_Gel1.pptx	Other
	C13Ac_2_Ac12KHST_F002946.dat	Other
	C13Ac_2_Ac13KHST_F002945.dat	Other

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Publications

Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity.

Lee Jiyoung J Manning Andrew J AJ Wolfgeher Donald D Jelenska Joanna J Cavanaugh Keri A KA Xu Huaqin H Fernandez Sandra M SM Michelmore Richard W RW Kron Stephen J SJ Greenberg Jean T JT

Cell reports 20151112 8

Modifications of plant immune complexes by secreted pathogen effectors can trigger strong immune responses mediated by the action of nucleotide binding-leucine-rich repeat immune receptors. Although some strains of the pathogen Pseudomonas syringae harbor effectors that individually can trigger immunity, the plant's response may be suppressed by other virulence factors. This work reveals a robust strategy for immune suppression mediated by HopZ3, an effector in the YopJ family of acetyltransfera ...[more]

PMID: 26586425

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