Proteomics

Dataset Information

0

Discovering new pneumococcal diagnostic tools protein-based


ABSTRACT: Thanks to surface digestion protocol above pneumococcal pediatric strains and in silico selection, we selected 94 pneumococcal proteins according to their surface-exposed domains and/or interactions with surface environment. Then, that proteins were cloned as recombinant form in Escherichia coli and face off to pediatric sera from control and pneumococcal patients.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Streptococcus Pneumoniae

TISSUE(S): Prokaryotic Cell, Cell Suspension Culture

DISEASE(S): Pleural Empyema

SUBMITTER: Alfonso Olaya Abril  

LAB HEAD: Manuel José Rodríguez Ortega

PROVIDER: PXD001740 | Pride | 2015-07-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
13H_02102012_121010154035.RAW Raw
13H_02102012_121010154035.msf Msf
13H_02102012_121010154035_peptides.xls Xls
13H_16052011.RAW Raw
13H_16052011.msf Msf
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Publications

A Pneumococcal Protein Array as a Platform to Discover Serodiagnostic Antigens Against Infection.

Olaya-Abril Alfonso A   Jiménez-Munguía Irene I   Gómez-Gascón Lidia L   Obando Ignacio I   Rodríguez-Ortega Manuel J MJ  

Molecular & cellular proteomics : MCP 20150716 10


Pneumonia is one of the most common and severe diseases associated with Streptococcus pneumoniae infections in children and adults. Etiological diagnosis of pneumococcal pneumonia in children is generally challenging because of limitations of diagnostic tests and interference with nasopharyngeal colonizing strains. Serological assays have recently gained interest to overcome some problems found with current diagnostic tests in pediatric pneumococcal pneumonia. To provide insight into this field,  ...[more]

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