Proteomics

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Urine proteome analysis in the differential diagnostics of respiratory tract pathology in newbornes under intensive care

ABSTRACT: To investigate the possibility of using modern mass spectrometric methods for forecasting, early diagnosis of the causes of respiratory diseases, as well as monitoring the effectiveness of treatment of newborns with very low and extremely low birth weight infants. Results: Based on the analysis of literature data and the results of their own research into the application of modern mass spectrometric methods for early diagnosis of the causes of respiratory disease in preterm infants developed the design of the proteomic analysis of urine of infants revealed characteristic differences of proteome urine of newborn children with respiratory disorders of various origins

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

DISEASE(S): Lower Respiratory Tract Disease

SUBMITTER: Vladimir Naumov  

LAB HEAD: Starodubtseva Nataliia Leonidovna

PROVIDER: PXD001773 | Pride | 2016-06-21

REPOSITORIES: Pride

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A serious problem during intensive care and nursing of premature infants is the invasiveness of many examination methods. Urine is an excellent source of potential biomarkers due to the safety of the collection procedure. The purpose of this study was to determine the features specific for the urine proteome of preterm newborns and their changes under respiratory pathologies of infectious and non-infectious origin. The urine proteome of 37 preterm neonates with respiratory diseases and 10 full-t  ...[more]

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