Dataset Information

BALF exosomes - Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules

ABSTRACT: Using 8-plex iTRAQ labelling exosmes isolated from bronchial lavage (BALF) were analyzed by LC-MS/MS. The measurements compared control subjects with sarcoidosis patients (15 in all) ; five with löfgrens syndrome and 10 with regular sacroidosis

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bronchoalveolar Lavage

DISEASE(S): Sarcoidosis

SUBMITTER: Robert Moulder

LAB HEAD: Susanne Gabrielsson

PROVIDER: PXD001808 | Pride | 2016-09-27

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	120229_RM_ExoTRAQ1_F21_110minrpt2.msf	Msf
	120229_RM_ExoTRAQ1_F22_110min.raw	Raw
	120229_RM_ExoTRAQ1_F23_110min.raw	Raw
	120229_RM_ExoTRAQ1_F24_110min.raw	Raw
	120229_RM_ExoTRAQ1_F25_110min.raw	Raw

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Publications

Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules.

Martinez-Bravo Maria-Jose MJ Wahlund Casper J E CJ Qazi Khaleda Rahman KR Moulder Robert R Lukic Ana A Rådmark Olof O Lahesmaa Riitta R Grunewald Johan J Eklund Anders A Gabrielsson Susanne S

The Journal of allergy and clinical immunology 20160823 4

<h4>Background</h4>Sarcoidosis is an inflammatory granulomatous disorder characterized by accumulation of T<sub>H</sub>1-type CD4<sup>+</sup> T cells and immune effector cells within affected organs, most frequently the lungs. Exosomes are extracellular vesicles conveying intercellular communication with possible diagnostic and therapeutic applications.<h4>Objectives</h4>We aimed to provide an understanding of the proinflammatory role of bronchoalveolar lavage fluid (BALF) exosomes in patients w ...[more]

PMID: 27566455

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