Proteomics

Dataset Information

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Olfactory neuroepithelial proteome in Schizophrenia & cannabis

ABSTRACT: In this study, we evaluated the common proteomic profile, as well as, the exclusively deregulated proteins in ON cells from healthy controls cannabis users (HC/c), SCZ patients non-cannabis users (SCZ/nc) and SCZ patients cannabis users (SCZ/c) as compared to healthy controls non-cannabis users (HC/nc). Moreover, we investigated quantitative and functional differences between HC/c and SCZ, and we characterized the distinct effect of cannabis in SCZ comparing SCZ/nc and SCZ/c.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Olfactory Epithelial Cell, Cell Culture

DISEASE(S): Schizophrenia

SUBMITTER: Enrique Santamaría  

LAB HEAD: Enrique Santamaria

PROVIDER: PXD020739 | Pride | 2021-09-09

REPOSITORIES: Pride

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Dataset's files

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1.1-162-Libreria_Dig.gel-11022019-11.wiff Wiff
1.1-162-Libreria_Dig.gel-11022019-11.wiff.scan Wiff
1.10-162-Libreria_Dig.gel-11022019-3.wiff Wiff
1.10-162-Libreria_Dig.gel-11022019-3.wiff.scan Wiff
1.11-162-Libreria_Dig.gel-11022019-2.wiff Wiff
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Publications

Cannabis Use Induces Distinctive Proteomic Alterations in Olfactory Neuroepithelial Cells of Schizophrenia Patients.

Barrera-Conde Marta M   Ausin Karina K   Lachén-Montes Mercedes M   Fernández-Irigoyen Joaquín J   Galindo Liliana L   Cuenca-Royo Aida A   Fernández-Avilés Cristina C   Pérez Víctor V   de la Torre Rafael R   Santamaría Enrique E   Robledo Patricia P  

Journal of personalized medicine 20210225 3

A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared t  ...[more]

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