Dataset Information
Molecular signatures after challenge with Salmonella Typhi implicate host tryptophan metabolism in the pathogenesis of typhoid fever, part 1
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Macrophage
DISEASE(S): Salmonella Infectious Disease
SUBMITTER: 
James Wright
LAB HEAD: Jyoti Choudhary
PROVIDER: PXD001953 | Pride | 2016-05-31
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 10AUG14_human_macrophages_17.raw | Raw | |||
| 10AUG14_human_macrophages_18.raw | Raw | |||
| 10AUG14_human_macrophages_19.raw | Raw | |||
| 10AUG14_human_macrophages_20.raw | Raw | |||
| 10AUG14_human_macrophages_21.raw | Raw |
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Publications
Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.
The Journal of experimental medicine 20160523 6
Enteric fever, caused by Salmonella enterica serovar Typhi, is an important public health problem in resource-limited settings and, despite decades of research, human responses to the infection are poorly understood. In 41 healthy adults experimentally infected with wild-type S. Typhi, we detected significant cytokine responses within 12 h of bacterial ingestion. These early responses did not correlate with subsequent clinical disease outcomes and likely indicate initial host-pathogen interactio ...[more]
