Proteomics

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Protein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)

ABSTRACT: his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western blot against the mutated protein TGFBIp that cause the protein accumulation in the cornea, was examined and compared to normal corneal tissue.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cornea

DISEASE(S): Corneal Granular Dystrophy

SUBMITTER: Ebbe Toftgaard Poulsen  

LAB HEAD: Jan Johannes Enghild

PROVIDER: PXD001997 | Pride | 2016-02-19

REPOSITORIES: Pride

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06864f1790fa6e72___2015-03-13 - ETP - GCDII C3-1.wiff.-1.pride.mgf.gz Wiff
06864f1790fa6e72___2015-03-13 - ETP - GCDII C3-2.wiff.-1.pride.mgf.gz Wiff
06864f1790fa6e72___2015-03-13 - ETP - GCDII C3-3.wiff.-1.pride.mgf.gz Wiff
06864f1790fa6e72___2015-03-13 - ETP - GCDII C4-1.wiff.-1.pride.mgf.gz Wiff
06864f1790fa6e72___2015-03-13 - ETP - GCDII C4-2.wiff.-1.pride.mgf.gz Wiff
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LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).

Poulsen Ebbe Toftgaard ET   Nielsen Nadia Sukusu NS   Jensen Morten M MM   Nielsen Esben E   Hjortdal Jesper J   Kim Eung Kweon EK   Enghild Jan J JJ  

Proteomics 20160103 3

More than 60 mutations in transforming growth factor beta-induced protein (TGFBIp) have been reported in humans causing a variety of phenotypic protein aggregates in the cornea, commonly termed corneal dystrophies. One mutation, generating an arginine to histidine amino acid substitution at position 124 in mature TGFBIp leads to granular corneal dystrophy type 2 (GCD2). Homozygous GCD2 cases develop massive protein accumulation early in life whereas heterozygous GCD2 cases become affected much l  ...[more]

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