Proteomics

Dataset Information

0

LPS-stimulated endothelial cells using SILAC

ABSTRACT: Severe sepsis and septic shock, which occur with high incidence and are prevalent in the emergency department setting, are among the most common causes of death in hospitalized patients worldwide, and there has been a continuous increase in the incidence of sepsis of approximately 5–10% per year. Endothelial cells constitute an important metabolic organ in the physiological homeostasis of blood vessels and play a pivotal role in orchestrating the inflammatory response triggered by sepsis or endotoxemia. The secretome is defined as the subset of the proteome that contains all the proteins actively exported by a cell following a particular event.

INSTRUMENT(S): LTQ FT

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vein Endothelial Cell, Cell Culture

SUBMITTER: Oh Kwang Kwon  

LAB HEAD: Sangkyu Lee

PROVIDER: PXD002220 | Pride | 2015-10-05

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
IPI_human_387.fasta Fasta
LPS_12hr_cell.dat-pride-filtered.pride.mgf.gz Mgf
LPS_12hr_cell.dat-pride-filtered.pride.mztab.gz Mztab
LPS_12hr_cell.dat-pride-filtered.xml.gz Xml
LPS_12hr_media.dat-pride-filtered.pride.mgf.gz Mgf
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Publications

In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells.

Kwon Oh Kwang OK   Lee Wonhwa W   Kim Sun Ju SJ   Lee You-Mie YM   Lee Ju Yeon JY   Kim Jin Young JY   Bae Jong-Sup JS   Lee Sangkyu S  

Electrophoresis 20150913 23

Sepsis and septic shock, which are conditions triggered by infection, occur with high incidence in emergency departments and are among the most common causes of death in hospitalized patients worldwide. Therefore, the identification of sepsis biomarkers for the rapid diagnosis is a major goal for researchers in the field of critical care. Endothelial cells play a pivotal role in orchestrating the inflammatory response triggered by sepsis. In this study, we used proteomics to investigate the secr  ...[more]

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