Ontology highlight
ABSTRACT:
Extra contact information:
Stephen Cusack, EMBL Grenoble Outstation, Unit of Virus Host-Cell Interactions, France ( corresponding author and lab head )
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Influenza A Virus (a/vietnam/1203/04(h5n1)) Influenza B Virus (b/memphis/13/03)
DISEASE(S): Influenza
SUBMITTER: Thomas Bock
LAB HEAD: Martin Beck
PROVIDER: PXD002234 | Pride | 2016-01-04
REPOSITORIES: Pride
Items per page: 1 - 5 of 51 |
Molecular cell 20151217 1
Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA ends (the promoter). In recent structures of promoter-bound polymerase, the cap-binding and endonuclease domains are configured for cap snatching, which generates capped transcription primers. Here, we present a FluB polymerase structure with a bound complementary cRNA 5' end that exhibits a maj ...[more]