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Proteomics Study of Molecular Mechanisms Involved in Early Pregnancy Loss

ABSTRACT: To identify the proteins and molecular signaling pathways that contribute to EPL, we performed proteomics and bioinformatics analysis of the placental villi in women who have undergone EPL and in normal pregnant women.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Embryo

SUBMITTER: Wei Ge

LAB HEAD: Wei Ge

PROVIDER: PXD002391 | Pride | 2016-03-11

REPOSITORIES: Pride

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			Action	DRS
	HUMAN.fasta	Fasta
	MS150170-T1.raw	Raw
	MS150170-T10.raw	Raw
	MS150170-T11.raw	Raw
	MS150170-T12.raw	Raw

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Publications

Proteomics study reveals that the dysregulation of focal adhesion and ribosome contribute to early pregnancy loss.

Xin Lingli L Xu Benhong B Ma Li L Hou Qingxiang Q Ye Mei M Meng Shu S Ding Xiaoping X Ge Wei W

Proteomics. Clinical applications 20160501 5

<h4>Purpose</h4>Early pregnancy loss (EPL) affects 50-70% pregnant women in first trimester. The precise molecular mechanisms underlying EPL are far from being fully understood. Therefore, we aim to identify the molecular signaling pathways relating to EPL.<h4>Experimental design</h4>We performed proteomics and bioinformatics analysis of the placental villi in women who have undergone EPL and in normal pregnant women. The proteomics data were validated by Western blot analysis.<h4>Results</h4>We ...[more]

PMID: 26947931

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Proteomics Study of Molecular Mechanisms Involved in Early Pregnancy Loss

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Project description:Total RNAs extracted from placental villi collected from women with (vaginal delivery) or without labor (cesarean section) at term (37-42 weeks of gestation) were hybridized to ClariomD microarrays and analyzed at the gene level to evaluate differential expression genes postlabor

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