Proteomics

Dataset Information

0

HLA-DR peptides from human BAL and EBV-transformed B cells


ABSTRACT: Optimization of the protocols for isolation HLA-DR (MHCII) peptides from human BAL.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Bronchoalveolar Lavage, Cell Culture, Macrophage

DISEASE(S): Idiopathic Interstitial Pneumonia,Sarcoidosis,Idiopathic Pulmonary Fibrosis

SUBMITTER: Jimmy Ytterberg  

LAB HEAD: Roman A. Zubarev

PROVIDER: PXD002439 | Pride | 2016-08-08

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20111214_03_V1_PAT1.raw Raw
20111214_03_V1_PAT1_Orbimzv2.mgf Mgf
20130301_03_Q3_PAT2.raw Raw
20130301_03_Q3_PAT2_Orbimzv2.mgf Mgf
20130301_04_Q3_PAT3.raw Raw
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Publications


Immune-mediated diseases strongly associating with human leukocyte antigen (HLA) alleles are likely linked to specific antigens. These antigens are presented to T cells in the form of peptides bound to HLA molecules on antigen presenting cells, e.g. dendritic cells, macrophages or B cells. The identification of HLA-DR-bound peptides presents a valuable tool to investigate the human immunopeptidome. The lung is likely a key player in the activation of potentially auto-aggressive T cells prior to  ...[more]

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