Proteomics

Dataset Information

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Inferior Temporal Gyrus in Human Ageing: a Quantitative Protein Profiling Work based on Chinese Human Brain Bank


ABSTRACT: The temporal lobe is the cerebral cortex with critical function. The superior and middle gyrus of temporal lobe have been well studied, however, present perceptions on inferior temporal gyrus remains limited. The understanding of age-related protein profile change in human inferior temporal gyrus has not yet been well established. This 3-plex TMT labeled proteomic study is performed based on the human brain bank at the Chinese Academy of Medical Sciences & Peking Union Medical College. Age distribution of the donors ranges from 22 to 90 years old, and were assigned to three age groups: 20-50, 50-70, and 70-90 years of death age. In this ageing cohort, no neurodegenerative disorders or major stroke events were identified via standard neuropathological classification. Proteomics and bioinformatics strategies were applied to identify the perturbations of protein expression and associated pathways. Among all the ITG samples, 3113 proteins were isolated, with 37 proteins upregulated and 21 proteins downregulated.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Wei Ge  

LAB HEAD: Wei Ge

PROVIDER: PXD002528 | Pride | 2015-12-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
HUMAN20140709.fasta Fasta
MS140697-T1.raw Raw
MS140697-T10.raw Raw
MS140697-T11.raw Raw
MS140697-T12.raw Raw
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Publications

Temporal lobe in human aging: A quantitative protein profiling study of samples from Chinese Human Brain Bank.

Xu Benhong B   Xiong Feng F   Tian Rui R   Zhan Shaohua S   Gao Yanpan Y   Qiu Wenying W   Wang Renzhi R   Ge Wei W   Ma Chao C  

Experimental gerontology 20151126


The temporal lobe is a portion of the cerebral cortex with critical functionality. The age-related protein profile changes in the human temporal lobe have not been previously studied. This 4-plex tandem mass tag labeled proteomic study was performed on samples of temporal lobe from Chinese donors. Tissue samples were assigned to four age groups: Group A (the young, age: 34±13 years); Group B (the elderly, 62±5 years); Group C (the aged, 84±4 years) and Group D (the old, 95±1 years). Pooled sampl  ...[more]

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