Dataset Information

Kaempferitrin-induced secretome analyses in rat CTX TNA2 astrocytic cell line

ABSTRACT: Kaempferitrin is extracted at significant quantity from leaves of Cinnamomum osmophloeum. People consuming extract containing kaempferitrin often happen to be of high risk for diabetes and neurodegenerative diseases. For kaempferitrin to be used every day for them, the systematic effect, especially on immune system and on the CNS, needs to be addressed. In this project we used astrocytic cell line as a model to test the differentially regulated secretomes, to test kaemfperitrin effect on CNS glia.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

SUBMITTER: Wei-Chi Ku

LAB HEAD: Wei-Chi Ku

PROVIDER: PXD002814 | Pride | 2017-11-24

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	140923KU03-LEEMG-SCX-EL30.raw	Raw
	140923KU04-LEEMG-SCX-EL30.raw	Raw
	140923KU05-LEEMG-SCX-EL30.raw	Raw
	140923KU06-LEEMG-SCX-EL60.raw	Raw
	140923KU07-LEEMG-SCX-EL60.raw	Raw

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Publications

A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells.

Ku Wei-Chi WC Chang Yi-Ling YL Wu Sheng-Fa SF Shih Hui-Nung HN Tzeng Yew-Min YM Kuo Hui-Ru HR Chang Kai-Ming KM Agrawal Dinesh Chandra DC Liu Bing-Lan BL Chang Chin-An CA Huang Siendong S Lee Meng-Jen MJ

Phytomedicine : international journal of phytotherapy and phytopharmacology 20170928

<h4>Ethnopharmacological relevance</h4>Kaempferitrin is extracted in significantly high quantities from the leaves of Cinnamomum osmophloeum (C.O) and Bauhinia forficata, and are used as an antidiabetic herbal remedy in China and Brazil. Commercial product using dry Cinnamomum osmophloeum leaves has been sold locally in Taiwan. Oral administration of kaempferitrin reduced blood sugar in diabetic rats.<h4>Aim of the study</h4>Though previously demonstrated to activate the classical insulin signal ...[more]

PMID: 29157807

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