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Ferlins and TgDOC2 in Toxoplasma microneme, rhoptry and dense granule secretion

ABSTRACT: Stable Isotope Labeling with Amino acids in Cell culture (SILAC) proteomics on the proteinsreleased in a set of T. gondii secretion mutants.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Toxoplasma Gondii Ctco5

SUBMITTER: Eranthie Weerapana

LAB HEAD: Eranthie Weerapana

PROVIDER: PXD024210 | Pride | 2021-09-10

REPOSITORIES: Pride

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			Action	DRS
	DN_FER1_BioRep_1.raw	Raw
	DN_FER1_BioRep_2.raw	Raw
	DTASelect-filter_DN_FER1_BioRep_1_heavy.txt	Txt
	DTASelect-filter_DN_FER1_BioRep_1_light.txt	Txt
	DTASelect-filter_DN_FER1_BioRep_2_heavy.txt	Txt

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Publications

Ferlins and TgDOC2 in Toxoplasma Microneme, Rhoptry and Dense Granule Secretion.

Tagoe Daniel N A DNA Drozda Allison A AA Falco Julia A JA Bechtel Tyler J TJ Weerapana Eranthie E Gubbels Marc-Jan MJ

Life (Basel, Switzerland) 20210309 3

The host cell invasion process of apicomplexan parasites like Toxoplasma gondii is facilitated by sequential exocytosis of the microneme, rhoptry and dense granule organelles. Exocytosis is facilitated by a double C2 domain (DOC2) protein family. This class of C2 domains is derived from an ancestral calcium (Ca2+) binding archetype, although this feature is optional in extant C2 domains. DOC2 domains provide combinatorial power to the C2 domain, which is further enhanced in fer ...[more]

PMID: 33803212

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