Dataset Information

Protein Turnover Rates in Normal and Hypertrophy Mouse Hearts

ABSTRACT: This dataset contains the in vivo turnover rate information of ~3,000 proteins from the mouse heart. Data from six common laboratory mouse strains with differential responses to isoproterenol are included

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Cardiocyte

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Edward Lau

LAB HEAD: Peipei Ping

PROVIDER: PXD002870 | Pride | 2015-09-22

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	AJ_CTRL_Heart_Cyto_d00_A01.raw	Raw
	AJ_CTRL_Heart_Cyto_d00_A02.raw	Raw
	AJ_CTRL_Heart_Cyto_d00_A03.raw	Raw
	AJ_CTRL_Heart_Cyto_d00_A04.raw	Raw
	AJ_CTRL_Heart_Cyto_d00_A05.raw	Raw

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Publications

A large dataset of protein dynamics in the mammalian heart proteome.

Lau Edward E Cao Quan Q Ng Dominic C M DC Bleakley Brian J BJ Dincer T Umut TU Bot Brian M BM Wang Ding D Liem David A DA Lam Maggie P Y MP Ge Junbo J Ping Peipei P

Scientific data 20160315

Protein stability is a major regulatory principle of protein function and cellular homeostasis. Despite limited understanding on mechanisms, disruption of protein turnover is widely implicated in diverse pathologies from heart failure to neurodegenerations. Information on global protein dynamics therefore has the potential to expand the depth and scope of disease phenotyping and therapeutic strategies. Using an integrated platform of metabolic labeling, high-resolution mass spectrometry and comp ...[more]

PMID: 26977904

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