Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Schizosaccharomyces Pombe
SUBMITTER: Triin Tammsalu
LAB HEAD: Genevieve Thon
PROVIDER: PXD002972 | Pride | 2015-10-30
REPOSITORIES: Pride
Items per page: 1 - 5 of 66 |
Nature communications 20151105
In eukaryotes, the conjugation of proteins to the small ubiquitin-like modifier (SUMO) regulates numerous cellular functions. A proportion of SUMO conjugates are targeted for degradation by SUMO-targeted ubiquitin ligases (STUbLs) and it has been proposed that the ubiquitin-selective chaperone Cdc48/p97-Ufd1-Npl4 facilitates this process. However, the extent to which the two pathways overlap, and how substrates are selected, remains unknown. Here we address these questions in fission yeast throu ...[more]