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Rs351855 knock-in Mouse Embryonic Fibroblasts

ABSTRACT: Proteomic alterations due to a single nucleotide change (rs351855;G/A) in the genome. Investigated by using MEFs derived from knock-in transgenic mice for either alleles

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Embryo, Fibroblast

DISEASE(S): Disease Free

SUBMITTER: Vijay Ulaganathan

LAB HEAD: Vijay Ulaganathan

PROVIDER: PXD003135 | Pride | 2016-01-19

REPOSITORIES: pride

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			Action	DRS
	20131106_EXQ1_s01.raw	Raw
	20131106_EXQ1_s02.raw	Raw
	20131106_EXQ1_s03.raw	Raw
	20131106_EXQ1_s04.raw	Raw
	20131106_EXQ1_s05.raw	Raw

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Publications

Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.

Ulaganathan Vijay K VK Sperl Bianca B Rapp Ulf R UR Ullrich Axel A

Nature 20151216 7583

Variant rs351855-G/A is a commonly occurring single-nucleotide polymorphism of coding regions in exon 9 of the fibroblast growth factor receptor FGFR4 (CD334) gene (c.1162G>A). It results in an amino-acid change at codon 388 from glycine to arginine (p.Gly388Arg) in the transmembrane domain of the receptor. Despite compelling genetic evidence for the association of this common variant with cancers of the bone, breast, colon, prostate, skin, lung, head and neck, as well as soft-tissue sarcomas an ...[more]

PMID: 26675719

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