Dataset Information

Germ-free mouse ileum iTRAQ shotgun LC-MSMS

ABSTRACT: Shotgun proteomics of normal versus germ-free mouse terminal ileum. 39 mice. Male and female. BALBc and C57BL10. The samples were labeled using iTRAQ 8plex and analyzed using a nano-LC-LTQ-Orbitrap-Velos-MSMS. This is the proteomics data from an n-omics project.

OTHER RELATED OMICS DATASETS IN: PRJNA377762

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Ileum

SUBMITTER: Aleksandra Nita-Lazar

LAB HEAD: Aleksandra Nita-Lazar

PROVIDER: PXD003177 | Pride | 2017-10-04

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	2014-12-18_3002_500ng_c1-9FT01_MS2.raw	Raw
	2014-12-18_3004_500ng_c1-9FT02_MS2.raw	Raw
	2014-12-18_3006_500ng_c1-9FT03_MS2.raw	Raw
	2014-12-18_3008_500ng_c1-9FT04_MS2.raw	Raw
	2014-12-18_3010_500ng_c1-9FT05_MS2.raw	Raw

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Publications

Multi-omics Comparative Analysis Reveals Multiple Layers of Host Signaling Pathway Regulation by the Gut Microbiota.

Manes Nathan P NP Shulzhenko Natalia N Nuccio Arthur G AG Azeem Sara S Morgun Andrey A Nita-Lazar Aleksandra A

mSystems 20170901 5

The bodies of mammals are hosts to vast microbial communities composed of trillions of bacteria from thousands of species, whose effects on health and development have begun to be appreciated only recently. In this investigation, an integrated analysis combining proteomics and transcriptomics was used to quantitatively compare the terminal ilia from conventional and germfree mice. Female and male mice responded similarly to the microbiota, but C57BL/10A mice responded more strongly than BALB/c m ...[more]

PMID: 29085914

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