Dataset Information
Deep mapping of the mouse podocyte proteome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Primary Cell, Epithelial Cell
SUBMITTER: 
Markus Rinschen
LAB HEAD: Thomas Benzing
PROVIDER: PXD003306 | Pride | 2018-06-21
REPOSITORIES: Pride
Dataset's files
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Publications
A Multi-layered Quantitative In Vivo Expression Atlas of the Podocyte Unravels Kidney Disease Candidate Genes.
Cell reports 20180501 8
Damage to and loss of glomerular podocytes has been identified as the culprit lesion in progressive kidney diseases. Here, we combine mass spectrometry-based proteomics with mRNA sequencing, bioinformatics, and hypothesis-driven studies to provide a comprehensive and quantitative map of mammalian podocytes that identifies unanticipated signaling pathways. Comparison of the in vivo datasets with proteomics data from podocyte cell cultures showed a limited value of available cell culture models. M ...[more]
