Proteomics

Dataset Information

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Aortic Aneurysm iTRAQ HiRIEF proteomics


ABSTRACT: Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher propensity of BAV patients to develop aorta dilation and consequent aortic aneurysm.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Aorta, Aortic Endothelial Cell

DISEASE(S): Aortic Aneurysm

SUBMITTER: Rui Branca  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD003702 | Pride | 2016-12-23

REPOSITORIES: Pride

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Publications

Mesenchymal state of intimal cells may explain higher propensity to ascending aortic aneurysm in bicuspid aortic valves.

Maleki Shohreh S   Kjellqvist Sanela S   Paloschi Valentina V   MagnĂ© Joelle J   Branca Rui Miguel Mamede RM   Du Lei L   Hultenby Kjell K   Petrini Johan J   Fuxe Jonas J   Lehtiö Janne J   Franco-Cereceda Anders A   Eriksson Per P   Björck Hanna M HM  

Scientific reports 20161025


Individuals with a bicuspid aortic valve (BAV) are at significantly higher risk of developing aortic complications than individuals with tricuspid aortic valves (TAV) and defective signaling during the embryonic development and/or life time exposure to abnormal hemodynamic have been proposed as underlying factors. However, an explanation for the molecular mechanisms of aortopathy in BAV has not yet been provided. We combined proteomics, RNA analyses, immunohistochemistry, and electron microscopy  ...[more]

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