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Surface Proteomics of Plasmodium yoelii Salivary Gland Sporozoites

ABSTRACT: To validate and refine bioinformatic tools aimed at identifying proteins found on the surface of the salivary gland sporozoites.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Plasmodium Yoelii

SUBMITTER: Scott Lindner

LAB HEAD: Scott Lindner

PROVIDER: PXD004018 | Pride | 2016-12-01

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	151027ASLSAM01409_SEL17.raw	Raw
	151027ASLSAM01410_SEL18.raw	Raw
	151027ASLSAM01411_SEL19.raw	Raw
	151027ASLSAM01412_SEL20.raw	Raw
	SEL17.tandem-comet.interact.prot.xml	Xml

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Publications

PlasmoSEP: Predicting surface-exposed proteins on the malaria parasite using semisupervised self-training and expert-annotated data.

El-Manzalawy Yasser Y Munoz Elyse E EE Lindner Scott E SE Honavar Vasant V

Proteomics 20161121 23

Accurate and comprehensive identification of surface-exposed proteins (SEPs) in parasites is a key step in developing novel subunit vaccines. However, the reliability of MS-based high-throughput methods for proteome-wide mapping of SEPs continues to be limited due to high rates of false positives (i.e., proteins mistakenly identified as surface exposed) as well as false negatives (i.e., SEPs not detected due to low expression or other technical limitations). We propose a framework called PlasmoS ...[more]

PMID: 27714937

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