Proteomics

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Proteomic Evaluation of PANDER TG Mice

ABSTRACT: Previous studies have demonstrated elevated circulating levels of PANcreatic DERived factor (PANDER) overexpression induced a selective hepatic insulin resistant phenotype in the liver of the PANDER transgenic mouse model. Here we utilized SILAC for "spike-in" as a quantitative mass spectrometry based proteomic workflow to reveal proteomic profile changes between the PANDER transgenic mouse and the wild-type mouse.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Mark Athanason  

LAB HEAD: Brant R. Burkhardt

PROVIDER: PXD004171 | Pride | 2016-09-29

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
FAST TG 587 from TG RAW_ MA_TG_LIV_SS_20131205_572_01 and 107 more.mzid_FAST_TG_587__from__TG_RAW__MA_TG_LIV_SS_20131205_572_01_and_107_more.pride.mgf.gz Mzid
FAST TG 587 from TG RAW_ MA_TG_LIV_SS_20131205_572_01 and 107 more.pride.mztab.gz Mztab
FAST TG 589 from TG RAW_ MA_TG_LIV_SS_20131205_572_01 and 107 more.mzid_FAST_TG_589__from__TG_RAW__MA_TG_LIV_SS_20131205_572_01_and_107_more.pride.mgf.gz Mzid
FAST TG 589 from TG RAW_ MA_TG_LIV_SS_20131205_572_01 and 107 more.pride.mztab.gz Mztab
FAST TG 607 from TG RAW_ MA_TG_LIV_SS_20131205_572_01 and 107 more.mzid_FAST_TG_607__from__TG_RAW__MA_TG_LIV_SS_20131205_572_01_and_107_more.pride.mgf.gz Mzid
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Publications

Hepatic SILAC proteomic data from PANDER transgenic model.

Athanason Mark G MG   Stevens Stanley M SM   Burkhardt Brant R BR  

Data in brief 20160816

This article contains raw and processed data related to research published in "Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis and Liver X Receptor Activation in the PANDER Transgenic Model" (M.G. Athanason, W.A. Ratliff, D. Chaput, C.B. MarElia, M.N. Kuehl, S.M., Jr. Stevens, B.R. Burkhardt (2016)) [1], and was generated by "spike-in" SILAC-based proteomic analysis of livers obtained from the PANcreatic-Derived factor (PANDER) transgenic mouse (PANTG) under various metabolic condit  ...[more]

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