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Role of macrophages in colitis

ABSTRACT: The goal of this project is to identify genes preferentially expressed in inflammatory macrophages as compared with control macrophages. inflammatory macrophage vs. control macrophage

ORGANISM(S): Mus musculus

SUBMITTER: Timothy Denning

PROVIDER: E-GEOD-68269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras Oscar O Harusato Akihito A Nishio Hikaru H Flannigan Kyle L KL Ngo Vu V Leoni Giovanna G Neumann Philipp-Alexander PA Geem Duke D Lili Loukia N LN Ramadas Ravisankar A RA Chassaing Benoit B Gewirtz Andrew T AT Kohlmeier Jacob E JE Parkos Charles A CA Towne Jennifer E JE Nusrat Asma A Denning Timothy L TL

Journal of immunology (Baltimore, Md. : 1950) 20151120 1

IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental colitis and human inflammatory bowel disease. Germ-free mice failed to induce IL-36γ in response to dextran sodium sulfate (DSS)-induced damage, suggesting that gut microbiota are involved in its induction. Surprisingly, IL-36R-deficient (Il1rl2(-/-)) mice exhibited defective recovery following DSS-induced damage and impaired closure of co ...[more]

PMID: 26590314

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Tissue macrophage subsets derived from regenerating muscle

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2016-04-07 | E-GEOD-71152 | biostudies-arrayexpress

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