Proteomics

Dataset Information

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C1R.B*57:01 MHC class I immunopeptidome LC-MSMS

ABSTRACT: Characterisation of peptide ligands of Major histocompatibility class (MHC) I isolated by immunoaffinity purification from the C1R (Class I reduced) B-lymphoblastoid cell line, transfected with the MHC class I allele HLA-B*57:01.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Patricia Illing  

LAB HEAD: Anthony W. Purcell

PROVIDER: PXD008570 | Pride | 2018-10-24

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
110728_mB5701_2017uniprotPilot5.group Other
110830_mB5701_2017uniprotPilot5.group Other
111206_mB5701_2017uniprotPilot5.group Other
111206_mB5701ex_2017uniprotPilot5.group Other
A1028July2011PatmB5701.wiff Wiff
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Publications

Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially associated with the HIV elite controller phenotype and adverse drug reactions. For each allotype,  ...[more]

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