Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA338920
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung
SUBMITTER: Tamar Ziv
LAB HEAD: Irit Sagi
PROVIDER: PXD004871 | Pride | 2019-11-19
REPOSITORIES: Pride
Action | DRS | |||
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Frank.rar | Other | |||
Seq35075_E2O2.raw | Raw | |||
Seq35076_E2O2.raw | Raw | |||
Seq35077_E2O2.raw | Raw |
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Cell host & microbe 20161001 4
Mounting an effective immune response, while also protecting tissue integrity, is critical for host survival. We used a combined genomic and proteomic approach to investigate the role of extracellular matrix (ECM) proteolysis in achieving this balance in the lung during influenza virus infection. We identified the membrane-tethered matrix metalloprotease MT1-MMP as a prominent host-ECM-remodeling collagenase in influenza infection. Selective inhibition of MT1-MMP protected the tissue from infect ...[more]