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Quantitative Shotgun Proteomics Unveils Candidate Novel Oesophageal Adenocarcinoma-Specific Proteins

ABSTRACT: Selective markers are needed for earlier diagnosis, optimal staging and treatment of oesophageal adenocarcinoma. This quantitative shotgun proteomic study used patient-matched fresh frozen tissue samples of OAC, normal oesophagus and normal stomach.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Gastric Epithelium, Esophageal Adenocarcinoma Cell, Esophageal Squamous Epithelium

DISEASE(S): Barrett's Adenocarcinoma

SUBMITTER: Robert O'Neill

LAB HEAD: Alexander Scherl

PROVIDER: PXD004962 | Pride | 2017-03-31

REPOSITORIES: Pride

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			Action	DRS
	2013_03_25_CAP_OT_61_HUP_PA60_F1.raw	Raw
	2013_03_25_CAP_OT_62_HUP_PA60_F2.raw	Raw
	2013_03_25_CAP_OT_63_HUP_PA60_F3.raw	Raw
	2013_03_25_CAP_OT_64_HUP_PA60_F4.raw	Raw
	2013_03_25_CAP_OT_65_HUP_PA60_F5.raw	Raw

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Quantitative Shotgun Proteomics Unveils Candidate Novel Esophageal Adenocarcinoma (EAC)-specific Proteins.

O'Neill J Robert JR Pak Hui-Song HS Pairo-Castineira Erola E Save Vicki V Paterson-Brown Simon S Nenutil Rudolf R Vojtěšek Bořivoj B Overton Ian I Scherl Alex A Hupp Ted R TR

Molecular & cellular proteomics : MCP 20170323 6

Esophageal cancer is the eighth most common cancer worldwide and the majority of patients have systemic disease at presentation. Esophageal adenocarcinoma (OAC), the predominant subtype in western countries, is largely resistant to current chemotherapy regimens. Selective markers are needed to enhance clinical staging and to allow targeted therapies yet there are minimal proteomic data on this cancer type. After histological review, lysates from OAC and matched normal esophageal and gastric samp ...[more]

PMID: 28336725

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