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Proteome changes during mouse brain aging

ABSTRACT: Analysis of proteome changes during mouse brain aging

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Jacek Wisniewski

LAB HEAD: Jacek R Wisniewski

PROVIDER: PXD005230 | Pride | 2018-07-30

REPOSITORIES: pride

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			Action	DRS
	20160630_QEp7_JRW_SA_L_Q100.raw	Raw
	20160630_QEp7_JRW_SA_L_Q101.raw	Raw
	20160630_QEp7_JRW_SA_L_Q102.raw	Raw
	20160630_QEp7_JRW_SA_L_Q103.raw	Raw
	20160630_QEp7_JRW_SA_L_Q104.raw	Raw

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Publications

Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging.

Duda Przemysław P Wójcicka Olga O Wiśniewski Jacek R JR Rakus Dariusz D

Aging 20180701 7

Aging is believed to be the result of alterations of protein expression and accumulation of changes in biomolecules. Although there are numerous reports demonstrating changes in protein expression in brain during aging, only few of them describe global changes at the protein level. Here, we present the deepest quantitative proteomic analysis of three brain regions, hippocampus, cortex and cerebellum, in mice aged 1 or 12 months, using the total protein approach technique. In all the brain region ...[more]

PMID: 30026405

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