Proteomics

Dataset Information

0

N-Linked Glycoprotein Profiles of Human Breast Claudin-Low Malignant Cell Lines

ABSTRACT: Secreted proteins and transmembrane proteins with extracellular domains are frequently glycosylated; this group of proteins includes those that participate in the various intercellular junctions and signaling pathways of an epithelium. In this study we characterized the differences in glycoprotein expression between claudin-low and other breast cell lines using a dataset of 26 breast cell lines in which the glycoproteins were identified and quantitated by liquid chromatography/ tandem mass spectrometry. Our goals are to characterize the glycoproteome of a set of claudin-low lines, compare them to basal, luminal and non-malignant cells and to identify drugs that may be especially effective on these cell lines. These five claudin-low malignant breast cells (BT549, HS578T, MDAMB157, MDAMB231 and MDAMB436) data are a part of 26 breast cell lines we analyzed.

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: Ten-Yang Yen  

LAB HEAD: Ten-Yang Yen

PROVIDER: PXD005292 | Pride | 2017-03-23

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
BT549-p49-51#1-061112-2D-2_N (F003262).mzid_BT549-p49-51_1-061112-2D-2_N_(F003262).pride.mgf.gz Mzid
BT549-p49-51#1-061112-2D-2_N (F003262).pride.mztab.gz Mztab
BT549-p49-51#1-061112-2D-3_N (F003263).mzid_BT549-p49-51_1-061112-2D-3_N_(F003263).pride.mgf.gz Mzid
BT549-p49-51#1-061112-2D-3_N (F003263).pride.mztab.gz Mztab
BT549-p49-51#1-061112-2D-4_N (F003264).mzid_BT549-p49-51_1-061112-2D-4_N_(F003264).pride.mgf.gz Mzid
Items per page:
1 - 5 of 500
altmetric image

Publications

Glycoproteins in Claudin-Low Breast Cancer Cell Lines Have a Unique Expression Profile.

Yen Ten-Yang TY   Bowen Spencer S   Yen Roger R   Piryatinska Alexandra A   Macher Bruce A BA   Timpe Leslie C LC  

Journal of proteome research 20170321 4

Claudin proteins are components of epithelial tight junctions; a subtype of breast cancer has been defined by the reduced expression of mRNA for claudins and other genes. Here, we characterize the expression of glycoproteins in breast cell lines for the claudin-low subtype using liquid chromatography/tandem mass spectrometry. Unsupervised clustering techniques reveal a group of claudin-low cell lines that is distinct from nonmalignant, basal, and luminal lines. The claudin-low cell lines express  ...[more]

Similar Datasets

Proteomics N-Linked Glycoprotein Profiles of Human Breast Basal Malignant Cell Lines
2017-03-27 | PXD005295 | Pride
Proteomics N-Linked Glycoprotein Profiles of Human Breast Luminal Malignant Cell Lines
2017-03-22 | PXD005390 | Pride
Proteomics N-Linked Glycoprotein Profiles of Human Breast Normal/Benign Cell Lines
2017-03-23 | PXD005339 | Pride
Proteomics,Multiomics Functional Proteogenomics Reveals Biomarkers and Therapeutic Targets in Lymphomas
2017-06-19 | PXD003469 | Pride
Proteomics Triple SILAC glycoproteomic analysis of NSCLC cell lines
2015-12-10 | PXD001999 | Pride
Proteomics cell surface glycoproteome liver and lung
2015-07-22 | PXD001988 | Pride
Proteomics Detergents assisted glycoprotein capture
2016-12-23 | PXD003485 | Pride
Proteomics Plasma proteomics of BACE1, 2, and double KO mice
2024-06-27 | PXD041577 | Pride
Proteomics Glycoproteomes of naive and LPS stimulated human monocytes and THP-1 cells
2017-04-24 | PXD004034 | Pride
Proteomics Multidimensional proteomic landscape of intercellular signaling in pancreatic cancer
2024-08-19 | PXD048644 | Pride