Dataset Information

Proteomics of PITHD1-deficient mice

ABSTRACT: To examine the functionality of PITHD1 on the olfactory molecular homeostasis in vivo, we applied olfactory proteomics in 6-week and 3-month-old PITHD1-/- mice. To analyze the potential differences in olfactory molecular expression profiles, OB specimens for each experimental group (PITHD1-/- and WT mice) were subjected to SWATH-MS.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD021634 | Pride | 2020-11-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Data215-LibreriaSDS-PAGE-1.wiff	Wiff
	Data215-LibreriaSDS-PAGE-1.wiff.scan	Wiff
	Data215-LibreriaSDS-PAGE-10.wiff	Wiff
	Data215-LibreriaSDS-PAGE-10.wiff.scan	Wiff
	Data215-LibreriaSDS-PAGE-11.wiff	Wiff

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Publications

Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism.

Lachén-Montes Mercedes M Mendizuri Naroa N Ausín Karina K Pérez-Mediavilla Alberto A Azkargorta Mikel M Iloro Ibon I Elortza Felix F Kondo Hiroyuki H Ohigashi Izumi I Ferrer Isidre I de la Torre Rafael R Robledo Patricia P Fernández-Irigoyen Joaquín J Santamaría Enrique E

Journal of proteome research 20201113 12

The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining in public resources and omics data sets derived from the human olfactory system. Multiple dark proteins localize at synaptic terminals and may be involved in amyloidopathies such as Alzheimer's disease (AD). We have characterized the dark PITH domain-containing protein 1 (PITHD1 ...[more]

PMID: 33185454

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