Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: Fabia Fricke
LAB HEAD: Prof. Juergen Kopitz
PROVIDER: PXD005620 | Pride | 2017-04-07
REPOSITORIES: Pride
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Cell communication and signaling : CCS 20170404 1
<h4>Background</h4>Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA sequences (microsatellites). These tumors recurrently show inactivating frameshift mutations in the tumor suppressor Transforming Growth Factor Beta Receptor Type 2 (TGFBR2) thereby abrogating downstream signaling. How altered TGFBR2 signaling affects exosome-mediated commu ...[more]