Proteomics

Dataset Information

0

Human serum proteome dynamics in type 2 diabetes using heavy water labeling mass spectrometry


ABSTRACT: Control subjects and type 2 diabetic patients were given deuterium-labeled (heavy) water for a seven-day period and their plasma serum proteins were analyzed by high-resolution mass spectrometry. Using an in-house-developed software, fractional synthesis rates were calculated for proteins of interest. These data can be used for qualitative, quantitative, and kinetics study of human serum proteins under healthy and type 2 diabetes conditions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Takhar Kasumov  

LAB HEAD: Takhar Kasumov

PROVIDER: PXD005755 | Pride | 2017-11-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
CO10_0h.mgf Mgf
CO10_0h.mzid.gz Mzid
CO10_0h.pride.mgf.gz Mgf
CO10_0h.pride.mztab.gz Mztab
CO10_0h.raw Raw
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Publications

Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Golizeh Makan M   Lee Kwangwon K   Ilchenko Serguei S   Ösme Abdullah A   Bena James J   Sadygov Rovshan G RG   Kashyap Sangeeta R SR   Kasumov Takhar T  

Free radical biology & medicine 20171025


Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and oxidative modification of plasma proteins are known to occur under hyperglycemia and oxidative stress. In this study, shotgun proteomics and <sup>2</sup>H<sub>2</sub>O-based metabolic labeling were used to characterize post-translational modifications a  ...[more]

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