Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, Lymph Node
SUBMITTER: Sri Ramarathinam
LAB HEAD: Anthony W Purcell
PROVIDER: PXD005935 | Pride | 2017-05-04
REPOSITORIES: Pride
Items per page: 1 - 5 of 34 |
Nature 20170503 7653
Susceptibility and protection against human autoimmune diseases, including type I diabetes, multiple sclerosis, and Goodpasture disease, is associated with particular human leukocyte antigen (HLA) alleles. However, the mechanisms underpinning such HLA-mediated effects on self-tolerance remain unclear. Here we investigate the molecular mechanism of Goodpasture disease, an HLA-linked autoimmune renal disorder characterized by an immunodominant CD4<sup>+</sup> T-cell self-epitope derived from the α ...[more]