Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Hela Cell
DISEASE(S): Cervical Adenocarcinoma
SUBMITTER: Rakesh Deshar
LAB HEAD: Jong-Bok Yoon
PROVIDER: PXD006156 | Pride | 2018-11-07
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
140912_RNF8_KGG_RK.mgf | Mgf | |||
140912_RNF8_KGG_RK.pride.mgf.gz | Mgf | |||
NONO-KGG-MGF.mgf | Mgf | |||
NONO-KGG-MGF.pride.mgf.gz | Mgf | |||
NONO-KGG-Mziden.mzid.gz | Mzid |
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Deshar Rakesh R Yoo Wonjin W Cho Eun-Bee EB Kim Sungjoo S Yoon Jong-Bok JB
Nucleic acids research 20190101 2
RNF8 plays a critical role in DNA damage response (DDR) to initiate ubiquitination-dependent signaling. To better characterize the role of RNF8 in UV-induced DDR, we searched for novel substrates of RNF8 and identified NONO as one intriguing substrate. We found that: (i) RNF8 ubiquitinates NONO and (ii) UV radiation triggers NONO ubiquitination and its subsequent degradation. Depletion of RNF8 inhibited UV-induced degradation of NONO, suggesting that RNF8 targets NONO for degradation in response ...[more]