Analysis of phospho-proteome change following MST3/4 depletion
Ontology highlight
ABSTRACT: Mammalian STE20-like protein kinases 3 and 4 (MST3/4) have recently emerged as crucial regulators of several key cellular processes such as proliferation, migration, and polarity. However, the downstream target pathways which are regulated by the kinase activity of MST3/4 remain poorly characterised. To assess downstream targets of MST3/4 kinases in an unbiased manner, we transiently co-depleted MST3 and MST4 in HeLa cells by siRNA and quantified the change in their phospho-proteome using SILAC.
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Cervix Carcinoma
SUBMITTER: Faraz Mardakheh
LAB HEAD: Faraz Mardakheh
PROVIDER: PXD006167 | Pride | 2022-02-28
REPOSITORIES: pride
ACCESS DATA