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In planta bacterial multi-omics illuminates regulatory principles underlying plant-pathogen interactions

ABSTRACT: Gene regulation of bacterial pathogens in the host is not comprehensively understood due to the difficulty in analyzing genome-wide mRNA and protein expression of bacteria during infection. Here, we jointly analyzed transcriptome and proteome of a foliar bacterial pathogen in plants. Bacterial transcriptome changes can explain to a large extent their proteome changes in resistant and susceptible plants. However, a part of bacterial type III secretion system was suppressed by plant immunity preferentially at the protein level. Also, gene co-expression analysis uncovered previously unknown gene regulatory modules underlying bacterial virulence. Collectively, integrated in planta bacterial omics provides molecular insights into multiple layers of bacterial gene regulation that contributes to virulence and roles of plant immunity in controlling it.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Arabidopsis Thaliana (mouse-ear Cress)

SUBMITTER: Sara Christina Stolze

LAB HEAD: Hirofumi Nakagami

PROVIDER: PXD015839 | Pride | 2020-04-30

REPOSITORIES: Pride

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Multidimensional gene regulatory landscape of a bacterial pathogen in plants.

Nobori Tatsuya T Wang Yiming Y Wu Jingni J Stolze Sara Christina SC Tsuda Yayoi Y Finkemeier Iris I Nakagami Hirofumi H Tsuda Kenichi K

Nature plants 20200615 7

Understanding the gene regulation of plant pathogens is crucial for pest control and thus global food security. An integrated understanding of bacterial gene regulation in the host is dependent on multi-omic datasets, but these are largely lacking. Here, we simultaneously characterized the transcriptome and proteome of a bacterial pathogen in plants. We found a number of bacterial processes affected by plant immunity at the transcriptome and proteome levels. For instance, salicylic acid-mediated ...[more]

PMID: 32541952

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Dataset Information

In planta bacterial multi-omics illuminates regulatory principles underlying plant-pathogen interactions

Dataset's files

Publications

Multidimensional gene regulatory landscape of a bacterial pathogen in plants.

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