Proteomics

Dataset Information

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A quantitative proteomic based approach for identifying and characterizing APAP-induced liver perturbation in zebrafish (Danio rerio)


ABSTRACT: The relative quantification of sex-specific proteomic responses led to the detection of potential biomarkers for hepatotoxicity and as well as the identification of the underlying molecular perturbation needed to unravel the impact of APAP-induced liver injury on physiological system.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Danio Rerio (zebrafish) (brachydanio Rerio)

TISSUE(S): Testis, Liver, Oocyte

SUBMITTER: Steve Ayobahan  

LAB HEAD: Dr. Elke Eilebrecht

PROVIDER: PXD013357 | Pride | 2019-11-18

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
LiverFemale_APAP.dta.zip Other
LiverFemale_APAP.fasta Fasta
LiverFemale_APAP.mgf Mgf
LiverFemale_APAP.pep.xml Pepxml
LiverFemale_APAP.prot.xml Xml
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Publications

Detection of biomarkers to differentiate endocrine disruption from hepatotoxicity in zebrafish (Danio rerio) using proteomics.

Ayobahan Steve U SU   Eilebrecht Sebastian S   Baumann Lisa L   Teigeler Matthias M   Hollert Henner H   Kalkhof Stefan S   Eilebrecht Elke E   Schäfers Christoph C  

Chemosphere 20190925


Measurement of specific biomarkers identified by proteomics provides a potential alternative method for risk assessment, which is required to discriminate between hepatotoxicity and endocrine disruption. In this study, adult zebrafish (Danio rerio) were exposed to the hepatotoxic substance acetaminophen (APAP) for 21 days, in a fish short-term reproduction assay (FSTRA). The molecular changes induced by APAP exposure were studied in liver and gonads by applying a previously developed combined FS  ...[more]

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