Proteomics

Dataset Information

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Results of the 3 times mass spectrometry experiments of YAP interacted proteins in liver cancer cells.


ABSTRACT: To determine the identities of the proteins co-purified with YAP and find new YAP-interacted transcription factors , we performed 3 times mass spectrometry experiments.

INSTRUMENT(S): 6520A Quadrupole Time-of-Flight LC/MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: Xiao Zhang  

LAB HEAD: Fenyong Sun

PROVIDER: PXD006601 | Pride | 2019-06-27

REPOSITORIES: Pride

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Publications

TFCP2 Is Required for YAP-Dependent Transcription to Stimulate Liver Malignancy.

Zhang Xiao X   Sun Fenyong F   Qiao Yongxia Y   Zheng Weisheng W   Liu Ya Y   Chen Yan Y   Wu Qi Q   Liu Xiangfan X   Zhu Guoqing G   Chen Yuxin Y   Yu Yongchun Y   Pan Qiuhui Q   Wang Jiayi J  

Cell reports 20171001 5


Although YAP-dependent transcription is closely associated with liver tumorigenesis, the mechanism by which YAP maintains its function is poorly understood. Here, we show that TFCP2 is required for YAP-dependent transcription and liver malignancy. Mechanistically, YAP function is stimulated by TFCP2 via a WW-PSY interaction. TFCP2 also maintains YAP stability by inhibiting βTrCP. Notably, genomic co-occupancy of YAP and TFCP2 is revealed. TFCP2 acts as a transcription co-factor that stimulates Y  ...[more]

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