Proteomics

Dataset Information

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Mtb BfrB interacted proteins - Systematic Identification of Mycobacterium tuberculosis Effectors Reveals that BfrB Suppresses Innate Immunity


ABSTRACT: To identify the protein interacted with Mtb BfrB, we performed the GST Pulldown assay followed by MS.We identified that Mtb BfrB interact with human RPS3.

INSTRUMENT(S): maXis

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: He Xiang  

LAB HEAD: He Xiang

PROVIDER: PXD006927 | Pride | 2017-10-17

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20140320_HX_2_GB7_01_3760.hdx Other
20140320_HX_2_GB7_01_3760.mgf Mgf
20140320_HX_2_GB7_01_3760.pride.mgf.gz Mgf
20140320_HX_2_GB7_01_3760.u2 Other
20140320_HX_2_GB7_01_3760.unt Other
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Publications

Systematic Identification of <i>Mycobacterium tuberculosis</i> Effectors Reveals that BfrB Suppresses Innate Immunity.

He Xiang X   Jiang He-Wei HW   Chen Hong H   Zhang Hai-Nan HN   Liu Yin Y   Xu Zhao-Wei ZW   Wu Fan-Lin FL   Guo Shu-Juan SJ   Hou Jing-Li JL   Yang Ming-Kun MK   Yan Wei W   Deng Jiao-Yu JY   Bi Li-Jun LJ   Zhang Xian-En XE   Tao Sheng-Ce SC  

Molecular & cellular proteomics : MCP 20171010 12


<i>Mycobacterium tuberculosis</i> (Mtb) has evolved multiple strategies to counter the human immune system. The effectors of Mtb play important roles in the interactions with the host. However, because of the lack of highly efficient strategies, there are only a handful of known Mtb effectors, thus hampering our understanding of Mtb pathogenesis. In this study, we probed Mtb proteome microarray with biotinylated whole-cell lysates of human macrophages, identifying 26 Mtb membrane proteins and se  ...[more]

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