Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Testis, Sperm
SUBMITTER: Christina Schiza
LAB HEAD: Eleftherios P. Diamandis
PROVIDER: PXD007515 | Pride | 2018-08-16
REPOSITORIES: Pride
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Schiza Christina C Korbakis Dimitrios D Panteleli Efstratia E Jarvi Keith K Drabovich Andrei P AP Diamandis Eleftherios P EP
Molecular & cellular proteomics : MCP 20180810 12
TEX101 is a testis-specific protein expressed exclusively in male germ cells and is a validated biomarker of male infertility. Studies in mice suggest that TEX101 is a cell-surface chaperone which regulates, through protein-protein interactions, the maturation of proteins involved in spermatozoa transit and oocyte binding. Male TEX101-null mice are sterile. Here, we identified by co-immunoprecipitation-mass spectrometry the interactome of human TEX101 in testicular tissues and spermatozoa. The t ...[more]