Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
SUBMITTER: Chia-yi Chen
LAB HEAD: Oliver Schilling
PROVIDER: PXD007691 | Pride | 2018-04-09
REPOSITORIES: pride
Chen Chia-Yi CY Melo Esther E Jakob Peter P Friedlein Arno A Elsässer Brigitta B Goettig Peter P Kueppers Verena V Delobel Frederic F Stucki Corinne C Dunkley Tom T Fauser Sascha S Schilling Oliver O Iacone Roberto R
Matrix biology : journal of the International Society for Matrix Biology 20180320
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population. Variants in the HTRA1-ARMS2 locus have been linked to increased AMD risk. In the present study we investigated the impact of elevated HtrA1 levels on the retina pigment epithelial (RPE) secretome using a polarized culture system. Upregulation of HtrA1 alters the abundance of key proteins involved in angiogenesis and extracellular matrix remodeling. Thrombospondin-1, an angiogenesis mo ...[more]