Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
DISEASE(S): Colon Cancer
SUBMITTER: AUDEBERT Stephane
LAB HEAD: Audebert Stephane
PROVIDER: PXD007765 | Pride | 2017-11-13
REPOSITORIES: Pride
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HMC1_Beads.raw | Raw | |||
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HMC1_Beads_140329010544.raw | Raw | |||
HMC1_Masitinib.raw | Raw | |||
HMC1_Masitinib_140329080705.raw | Raw |
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Nature communications 20171110 1
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. Here we report a reverse proteomic approach that identifies the target responsible for this sensitisation: the deoxycytidine kinase (dCK). Masitinib, as well as other protein kinase inhibitors, such as imatinib, interact with dCK and provoke an unforeseen conformational-dependent activation of this nucleoside kinase, modulating phosphorylation ...[more]