Proteomics

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Influenza A virus induces autophagosomal targeting of ribosomal proteins

ABSTRACT: Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective anti-viral therapies, a detailed knowledge of cellular pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to identify new protein targets and cellular pathways affected by influenza A virus. Type I as well as type II interferon pathways were upregulated upon infection, affecting amongst others poly ADP-ribose polymerase transcription factors and ubiquitin-like modifiers. In addition, influenza A virus had a major influence on the subcellular localization of proteins and complexes. The vesicular compartment appeared expanded upon infection and in particular the composition of autophagsomes was altered, virus infection leading to targeting of ribosomes to autophagosomes.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Influenza

SUBMITTER: Joern Dengjel  

LAB HEAD: Joern Dengjel

PROVIDER: PXD007809 | Pride | 2018-07-12

REPOSITORIES: Pride

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20080315jd_flu2_08.RAW Raw
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Seasonal epidemics of influenza A virus are a major cause of severe illness and are of high socio-economic relevance. For the design of effective antiviral therapies, a detailed knowledge of pathways perturbed by virus infection is critical. We performed comprehensive expression and organellar proteomics experiments to study the cellular consequences of influenza A virus infection using three human epithelial cell lines derived from human lung carcinomas: A549, Calu-1 and NCI-H1299. As a common  ...[more]

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