Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap, Synapt MS
ORGANISM(S): Homo Sapiens (human) Cricetulus Griseus (chinese Hamster) (cricetulus Barabensis Griseus)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: Bogdan Florea
LAB HEAD: Mario van der Stelt
PROVIDER: PXD008460 | Pride | 2018-06-15
REPOSITORIES: Pride
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Journal of the American Chemical Society 20180216 19
Chemical tools and methods that report on G protein-coupled receptor (GPCR) expression levels and receptor occupancy by small molecules are highly desirable. We report the development of LEI121 as a photoreactive probe to study the type 2 cannabinoid receptor (CB<sub>2</sub>R), a promising GPCR to treat tissue injury and inflammatory diseases. LEI121 is the first CB<sub>2</sub>R-selective bifunctional probe that covalently captures CB<sub>2</sub>R upon photoactivation. An incorporated alkyne ser ...[more]