Proteomics

Dataset Information

0

Integrated FTIR imaging and proteomics for identification of a candidate histochemical biomarker in bladder cancer


ABSTRACT: A quantitative label-free proteome analysis of cystitis and high-grade bladder cancer tissue priorly annotated and isolated via FTIR-guided lasermicrodissection.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urinary Bladder, Bladder Urothelial Cell

DISEASE(S): Bladder Transitional Cell Carcinoma

SUBMITTER: Thilo Bracht  

LAB HEAD: Barbara Sitek

PROVIDER: PXD009203 | Pride | 2019-08-13

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
OEI17245.mgf Mgf
OEI17245.msf Msf
OEI17245.mzid.gz Mzid
OEI17245.pride.mgf.gz Mgf
OEI17245.pride.mztab.gz Mztab
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Publications


Histopathological differentiation between severe urocystitis with reactive urothelial atypia and carcinoma in situ (CIS) can be difficult, particularly after a treatment that deliberately induces an inflammatory reaction, such as intravesical instillation of Bacillus Calmette-Guèrin. However, precise grading in bladder cancer is critical for therapeutic decision making and thus requires reliable immunohistochemical biomarkers. Herein, an exemplary potential biomarker in bladder cancer was identi  ...[more]

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