Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion, Q Exactive HF
ORGANISM(S): Synthetic Construct (code 12)
SUBMITTER: Bernd Roschitzki
LAB HEAD: Prof. Markus Seeger
PROVIDER: PXD009301 | Pride | 2019-01-15
REPOSITORIES: Pride
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20160809_NL3idx6_expBtoC_06_B_BG.raw | Raw | |||
20160809_NL3idx6_expBtoC_09_B_MBP.raw | Raw | |||
20170303_04_aOMP_Ecoli1.raw | Raw | |||
20170303_05_aOMP_Ecoli2.raw | Raw | |||
20170303_06_aOMP_Ecoli3.raw | Raw |
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Nature methods 20190422 5
Binding protein generation typically relies on laborious screening cascades that process candidate molecules individually. We have developed NestLink, a binder selection and identification technology able to biophysically characterize thousands of library members at once without the need to handle individual clones at any stage of the process. NestLink uses genetically encoded barcoding peptides termed flycodes, which were designed for maximal detectability by mass spectrometry and support accur ...[more]