Dataset Information

Molecular changes during extended endocrine treatment of breast cancer

ABSTRACT: Sequential patient-matched samples treated with extended neoadjuvant therapy were studied. Samples were classified as pre-treatment (timepoint1, <0 days), early-on treatment (timepoint2, 0-120 days) and long-term treatment (timepoint4, >120 days).

OTHER RELATED OMICS DATASETS IN: GSE111563

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Cigdem Selli

LAB HEAD: Andrew H Sims

PROVIDER: PXD009328 | Pride | 2019-02-27

REPOSITORIES: Pride

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Publications

Molecular changes during extended neoadjuvant letrozole treatment of breast cancer: distinguishing acquired resistance from dormant tumours.

Selli Cigdem C Turnbull Arran K AK Pearce Dominic A DA Li Ang A Fernando Anu A Wills Jimi J Renshaw Lorna L Thomas Jeremy S JS Dixon J Michael JM Sims Andrew H AH

Breast cancer research : BCR 20190107 1

<h4>Background</h4>The risk of recurrence for endocrine-treated breast cancer patients persists for many years or even decades following surgery and apparently successful adjuvant therapy. This period of dormancy and acquired resistance is inherently difficult to investigate; previous efforts have been limited to in-vitro or in-vivo approaches. In this study, sequential tumour samples from patients receiving extended neoadjuvant aromatase inhibitor therapy were characterised as a novel clinical ...[more]

PMID: 30616553

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